aminophylline infusion calculation

Infusion rate by at least 50 L Adverse reactions symptoms with risk of further reaction. For patient who HAVE had theophylline in the past 24 hours based on theophylline serum concentration measurements in mcgmL.

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0008 x age in weeks 021 theophylline dosage in mgkghour IV.

. Rate 05 mgkghour rate is half patients weight see table below Dose and rate of aminophylline 1 mgml infusion Patient weight - kg use IBW if patient obese Dose mghr Infusion rate mlhr 40 20 20. For intravenous theophylline aminophylline guidelines and formularies recommend a target therapeutic range between 10 and 20 mgl with the commonest regimen being a loading dose of 5 mgkg followed by an infusion calculated by age and weight. The giving set delivers 20 dropsmL.

Site map Accessibility Contact us. Aminophylline infusion rate mgkghr Neonates. Therefore in a patient who has received no theophylline in the previous 24 hours a loading dose of intravenous theophylline of 46 mgkg 57 mgkg as aminophylline calculated on the basis of ideal body weight and administered over 30 minutes on average will produce a maximum post-distribution serum concentration of 10 mcgmL with a range of 6-16 mcgmL.

This example indicates how many mLs to give in a certain time and how many drops per minute a patient will receive. Dose desired serum theophylline concentration - measured serum theophylline concentration Vd -Acute symptoms. Postnatal age up to 24 days.

Draw up 10ml of 250mg in 10ml aminophylline 1 ampoule and add this to the bag You now have 250mg of aminophylline in 250ml of fluid 1mg ml b Calculate the Infusion Rate of Aminophylline Solution 1mgml The usual dose range as stated in the BNFC1 and SORT2 guidelines. Blood samples were drawn before treatment for theophylline-content measurement. This dose is then divided by the daily frequency of oral theophylline administration.

Under 12 Years 1 milligramkghour 12-17 years 05 to 07 milligramkghour. Show less Show more. 101 mgkghr 08 mgkghr Older children.

A pharmacokinetic method of establishing individualized doses of aminophylline in patients with acute bronchospasm was evaluated. Aminophylline Injection BP may be given by slow intravenous injection or intravenous infusion in glucose injection or sodium chloride injection. Aminophylline is a stable mixture or combination of theophylline and ethylenediamine.

Should be calculated as follows. This dose mgday is then multiplied by 08adjustment for the ethylenediamine component of aminophyllineto yield the total daily dose of theophylline. Infusion rate by 25 20 to 249 Controlled Adverse reactions are present Stop infusion for 24 hours subsequent infusion rate at least 25 Adverse reactions symptoms Stop infusion for 24 hours.

Aminophylline - infusion is a drug to address respiratory distress for children with severe asthma. Reduced doses may be needed in patients with risk factors for reduced theophylline clearance eg cardiac or liver dysfunction renal. Calculate the drip rate.

By registering you consent to the collection and use. Aminophylline has a narrow therapeutic index therefore cautious dosage determination is essential. 300microgramskghour 300micrograms x 55kg per hour 16500 micrograms 165mg 17mg per hour Add 250mg aminophylline to 250ml infusion fluid 1mgml concentration Set rate controlled infusion pump at 17ml per hour.

5mgkg 5mg x 55kg 275mg- add to 100ml infusion fluid and administer over 20 minutes Maintenance dose. Calculate initial dosage using the following equation. Lower initial doses may be required in patients with reduced theophylline clearance.

190 mgkg q 12h 15 mgkg q 12h Infants. -Loading dose Desired concentration - measured concentration volume of distribution -Mean volume of distribution can be assumed to be 05 Lkg actual range 03 to 07. If this is not possible and if the clinical situation requires that the drug be administered a dose of 31 mgkg of aminophylline equivalent to 25mgkg of anhydrous theophylline may be considered on the basis that it is likely to increase the serum theophylline concentration by approximately 5mcgml when administered as a loading dose.

Patients admitted to a hospital who required intravenous aminophylline for bronchodilation were studied. To achieve a target theophylline concentration of 10 mcgml unless otherwise noted. Theophylline is metabolised in the liver.

Aminophylline infusion Find mghr DO mlhr SH gmml Dosage Calculation common icu drips icu iv drips icu drips management. Therapeutic serum concentrations of theophylline are considered to range from 10 to 20 mcgml and levels. Skip to main content.

Loading doses were administered intravenously and half. Aminophylline infusion rate mghour is multiplied by 24 to yield total daily dose of aminophylline. Mgkghr0008age in weeks 021079 0008age in weeks021 Young children.

The plasma-theophylline concentration is increased in heart failure hepatic impairment and in viral infections. Dilute 500mg aminophylline in 500 mL sodium chloride 09 or glucose 5 to give a 1 mgml solution Administration. 127 mgkg q 12h 10 mgkg q 12h Postnatal age beyond 24 days.

A teenager who is badly dehydrated is to receive 15 L over 10 hours of rehydration fluid by IV infusion. Department of Health. I would like to receive relevant information via email from MPR Haymarket Medical Network.

Go to whole of WA Government Search. Each 05mgkg aminophylline administered as a loading dose gives rise to a 1mcgml increase in serum concentrations of theophylline Patient is obese if actual body weight is 20 or more above ideal body weight or BMI 30 ref 3 Ideal body weight IBW calculations Male 50kg 23 x inches over 5 feet or 50kg 09 x cm over 152 cm. The ethylenediamine confers greater solubility in water.

Consider if overdose treatment required.

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